100MG/ML and each pump of the spray delivers 0.1ml, which is about 10mg of ketamine. Volume of each bottle is 20ML.

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ketamine nasal spray According to Dr. Anand, the medication is a kind of ketamine, a generic medicine that has long been employed as an anesthetic.

For individuals with depression who are resistant to therapy, ketamine has also been used for years at lesser dosages administered intravenously. However, because it is a generic medicine, it has not undergone FDA evaluation for that usage. nasal spray for ketamine

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It is really a prohibited narcotic, known as Special K, and is occasionally abused as a recreational drug. The new esketamine nasal spray will only be utilized in a doctor’s office or hospital environment due to this plus the fact that it might trigger sensations of dissociation and delusion in those who take it.

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“It’s a slightly different form of ketamine and will be given as nasal puffs, but the effects are essentially the same,” Dr. Anand says.

Once or twice a week, a patient will visit their doctor to get nasal sprays of an esketamine dosage.

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They will remain in the doctor’s office for two hours because they could feel disoriented or confused right away. For the remainder of the day, they are also recommended from using machinery, operating a vehicle, or performing any other activities that demand concentration.

Esketamine nasal spray for treatment-resistant depression looks to be both efficient and quick-acting.

Why is Ketamine nasal spray promising

The fast-acting nature of the new medication is one possible advantage. According to Dr. Anand, people may see a reduction in symptoms within a few hours, and it may linger for many days. On the other hand, the majority of oral antidepressants might take weeks to start functioning.

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This is so because it functions differently from other depression medications. Ketamine has significant impacts on glutamate, a distinct neurotransmitter that is considerably more prominent in the brain, which is far more so than most other existing antidepressants, according to Dr. Anand.

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Side Effects Ketamine nasal spray

The most frequent adverse effects of the medication included nausea, vertigo, dysgeusia (a shift or distortion in taste perception), dysgeusia, and dizziness. The majority often started soon after dose and went away in 90 minutes. Nevertheless, the study’s findings generally supported the drug’s safety and tolerability.

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An imperfect solution

Ketamine does have disadvantages aside from potential adverse effects. Although it has been used successfully as a short-term anesthetic and at lesser dosages as a short-term antidepressant, physicians are still unsure of its safety and efficacy when administered for several months or years.

The ramifications of a long-term disruption of a key neurochemical in the brain, which this medication affects, remain unknown, according to Dr. Anand. It is also an addictive substance, and users may abuse or overdo it.

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Additionally, there is no assurance that it will be effective in all populations of patients with treatment-resistant depression. Additionally, it is always possible that it might exacerbate symptoms like other antidepressants.

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Before it was approved, esketamine was examined in five clinical studies. According to Dr. Anand, just one short-term experiment and its subsequent, longer-term relapse prevention trial of patients who had benefitted with ketamine achieved statistically significant beneficial outcomes. Another research indicated that the effectiveness of antidepressant and ketamine therapy did not approach statistical significance in individuals who were above the age of 65.



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