How to Used ketamine to treat depression


Ketamine is a dissociative drug with hallucinogenic properties. Dissociative means that there is a chance that your body and mind will ‘separate’ from each other. This can result in a K-hole or an out-of-body experience, but this does not happen after a single dose. The drug is used as an anesthetic in both veterinary medicine and hospitals. Ketamine is also used to treat Depression. Anxiety, pain and so much more.

What is ketamine?

Ketamine Dosage for Depression

Based on
body weight
(mg / kg)
Threshold10 – 150.2
Low15 – 300.35
Average30 – 750.65
High **75-1501 – 1.65
Very high **150+2+
Ketamine dosage

* The effects of a dose depend on your weight, the following is based on someone weighing 55 kg and above.
** From this dose range, the chance of a K-hole increases considerably, someone weighing 50 kg could already end up in a K-hole from 100 mg.

How Long Does Ketamine Stay In your System?

13 hours maximum

Total60 – 120 minutes
Attendance5 – 15 minutes
Peak30 – 60 minutes
After Effects13 hours

What are the Uses for ketamine?

Medical uses for Ketamine

  • Depressive symptoms seem to diminish for about a week after a Ketamine therapy session under the influence of ketamine. Since the early 2000s, more than 1,000 studies have been started on these antidepressant effects of the drug.
  • Ketamine is used as an anesthetic in veterinary medicine and in hospitals.
  • Ketamine can also be used as a painkiller during serious accidents

To combine: Combining Ketamine with other Downers

Ketamine is an anesthetic and therefore a ‘downer’. This means that you should not combine the drug with other downers, as this can cause breathing to stop and increase the risk of choking on your own vomit. Combining ketamine with cocaine, amphetamine and other stimulants is not recommended, as it increases the risk of heart attacks.

Do not combine Ketamine with:
  • Alcohol
  • GHB
  • Benzodiazepines
  • Opiates
  • MAOIs

Not recommended:

The Good and Bad Effects Of Ketamine

Psychological Effects of Ketamine

In low doses of ketamine feels a bit dreamy, hazy, and maybe a bit mealy. At a medium to high dose you can become a bit more confused and at very high doses you can lose connection with reality and even end up in a K-hole.

  • Forgetfulness
  • Decrease in hazard perception
  • Decrease in personal inhibitions
  • Decrease / loss of sense of time
  • Dreamy feeling
  • Euphoria
  • Confusion
  • The feeling that everything is connected

Physical Effects of Ketamine

In low doses, your fingers / limbs may tingle a bit and you may find it difficult to coordinate your movements. As soon as you increase the dose, you may even lose some or all of the feeling in your limbs.

  • Increased saliva production
  • Disorientation
  • Difficulty coordinating movements (like walking on the moon, feeling like a robot)
  • Nausea
  • Stiff muscles
  • Tingling limbs / fingers
  • Limb numbness
  • Dizziness
  • Less sex drive
  • Palpitations

Hallucinogenic Effects of Ketamine

At a low dose you will probably not notice the hallucinogenic effects. From an average dose it may be that the angles and lengths of objects no longer seem to be correct. You may also see geometric shapes, colors or patterns with your eyes closed.

  • Seeing patterns, colors or other geometric shapes with closed eyes
  • Blurry sight
  • See fewer frames per second than normal
  • Angles and lengths of objects are incorrect
  • Synesthesia (fusion of the senses; colors are tasted, sounds are seen, etc.)
  • The vision is divided into ‘slices’ that seem to move separately (at high doses)

Dissociative Effects of Ketamine

In addition to psychological, physical and hallucinogenic effects, ketamine also has dissociative effects. The extent to which these are experienced depends very much on the dose. At a high dose, the chance of an out-of-body experience and a K-hole increases.

  • Feeling that limbs no longer belong to the body
  • Feeling like limbs are larger or smaller than normal
  • No more idea whether a limb belongs to you, someone else or the environment
  • The idea that mind and body are separate
  • A K-hole

What is K-Hole

A K-hole is a very intense ketamine experience that is a bit different for everyone. Users often label a (desired) K-hole as a mystical experience, but it can also be frightening. There is no fixed dose for a K-hole because everyone is different, but a K-hole only occurs with high doses of ketamine

After Effects of Using Ketamine for Depression

You may have trouble falling asleep right after the ketamine wears off. In general, users don’t really experience a hangover the day after use. You may, however, have a little less energy than normal, because you slept less.

Risks of Using Ketamine for Depression

Acute health

  • Injuries
  • Accidents
  • Palpitations
  • Dizziness
  • Nausea
  • Choking on your own vomit *  (small chance)

* If you feel nauseous during the trip, you may be vomiting. If this happens while lying on your back in a K-hole, it can be fatal. You can prevent this by not lying on your back.

Chronic Health

  • Memory disorders
  • Addiction
  • Psychoses
  • Tolerance
  • Bladder cancer *
  • Increased risk of bladder infections *

* Chronic ketamine users (several grams per day, at least 20 days per month) are likely to have an increased risk of bladder cancer and other bladder problems such as bladder infections.

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